Ng Lai Guan 黄来源
研究员 博士生导师
西湖大学 教授
Google Scholar：https://shorturl.at/hkDM6
研究方向
1.中性粒细胞和单核细胞的分化机制和迁徙特性
2.中性粒细胞在肿瘤中的异质性
3.中性粒细胞在2型糖尿病中的功能研究
教育经历
2001-2004 新南威尔士大学 免疫学 博士
2000-2001 新南威尔士大学 药理学 荣誉学士
1997-2000 悉尼大学 医药科学 本科
工作经历
2025-至今 西湖大学
2023-2025 上海交通大学医学院附属仁济医院 资深研究员
2009-2023 新加坡免疫学网络中心 首席研究员
2007-2009 悉尼大学 博士后
2006-2007 威斯塔研究所 博士后
2004-2006 新加坡科技局分子和细胞生物学研究院 博士后
荣誉奖项
2018年 年度新加坡科技局“良师益友”奖（The Most Inspiring Mentor (A*STAR)，2018）
2020年 年度论文高被引用科学家（Highly Cited Researcher (Web of Science）)
2021年 年度论文高被引用科学家（Highly Cited Researcher (Web of Science）)
2022年 年度论文高被引用科学家（Highly Cited Researcher (Web of Science）)
2023年 年度论文高被引用科学家（Highly Cited Researcher (Web of Science）)
2022年 长江学者奖励计划讲席学者
2022年 上海市领军人才（海外）创新人才
2023年 上海高层次人才计划
2024年 年度论文高被引用科学家（Highly Cited Researcher (Web of Science）)
学术职务
中国细胞生物学学会免疫细胞生物学分会委员
中国生物化学与分子生物学会分子免疫专业分会委员
中国生理学会血液生理专业委员
Science Immunology编委
Discovery Immunology期刊高级主编
Journal of Leukocyte Biology期刊副主编
Cellular Immunology期刊编委
专利
1. SG Patent Application no: 10201602701S. A multimodal gluorescent probe for detecting vascular integrity and leakage
2. SG Patent Application no: 10202005589P. CD71 biomarker defines human neutrophil progenitors
3. Provisional Patent Application no: 10201800714R. Identification of human neutrophil developmental heterogeneity in healthy and diseased-state
4.International Application no: PCT/SG2019/050040. Neutrophi l subtype
5. SG Patent Application no: 10202012586X. A method of characterising an immunosuppressive neutrophil
6. SG Patent Application no: 10202012393V. A method for evaluating progression of an infectious disease and/or inflammatory disease
基金项目
1. 澳大利亚国家健康与医学研究委员会（NHMRC）创新资助计划，解析肿瘤免疫生态系统的神经调控机制（2038669），2025-2029，中方负责人
2. 国家自然科学基金外国专家项目，中性粒细胞来源的胶原蛋白在肿瘤进展中的作用机制研究（W2431020），2025-2026，主持
3. 国家自然科学基金重大研究计划，综合中性粒细胞多组学数据解锁自身免疫病的生物标志物和治疗靶点（92374205），2024-2027，主持
4. 国家科学技术部重点研发专项，阐明天然效应分子介导迁徙性细胞捕捉与清除病原体的机制（2023YFC2306302），2024-2026，课题负责人
5. 国家科学技术部重点研发专项，阐明免疫新机制推动模型校正与方案优化（2023YFC2506405），2023-2026，课题骨干
6. 国家自然科学基金面上项目，肿瘤相关中性粒细胞的异质性研究（32270956），2023-2026，主持
7. 国家科技部，中性粒细胞在糖尿病状态及血糖稳态条件下对创口愈合作用的研究，2022-2024，主持
8. Shared Infrastructre Support Grant (SIS): SingaScope: A Singapore-wide Micrscoppy Network (NRF2017_SISFP10). 2019-2024. PI: Graham Wright, Co-I: L. G. Ng
9. Industry Alignment Fund (Pre-positioning): SInGapore ImmuNogrAm for Immuno-OncoLogy (SIGNAL) (H19/01/a0/024). 2019-2023. PI: Laurent Renia and David Tan, Imaging Theme Co-PI: L. G. Ng
10. Industry Alignment Fund (Pre-positioning): Cancer ImmunoTherapy Imaging (CITI) Programme: Precision Immune Cell Imaging for Precision Cancer Immunotherapy (H18/01/a0/018). 2018-2023.PI: Ann-Marie Chacko and Daniel Tan, Imaging Theme Co-I: L. G. Ng
11. Skin Innovation Grant: Modulation of Biomaterial-mediated wound healing response by biomimetic polymeric surface (SIG18027). 2018-2020. PI: Dang Thuy Tram, Co-I: L.G. Ng
12. NMRC Clinician Scientist Award: Three-dimensional imaging in ex vivo skin and non-invasive skin imaging: novel clinical applications in skin cancers and hypohidrotic sweat disorders (SRG/14019). 2018-2021. Clinical PI: Tey Hong Liang, Co-I: L. G. Ng
13. NHMRC Project Grants: A unique network of phagocytic cells at the interface between the liver and peritoneal cavity. 2016-2019. CIA: P. Bertolino, CIB: D. Bowen, CIC: B. Saunders and CID: L.G. Ng
14. NHMRC Project Grants: Dynamics and mechanisms of immune complex-mediated skin inflammation. 2016-2019. CIA: W. Weninger and CIB: L.G. Ng
15. NHG Small Innovative Grants: Genomic Profiling of Type III hypersensitivity in Cutaneous Vasculitis (SIG/15501). 2015-2017. Clinical PI: H.L. Tay, Non-Clinical PI: L.G. Ng
16. NMRC Coorperative Basic Research Grant: Mast cell-driven T cell responses during acute viral infection (NMRC/CBRG/0084/2015). 2015-2018. Principal Investigator: A.L. St John, Co-I: L.G. Ng and Lisa Ng
17. A-STAR-NHG-NTU Skin Research Grants: Pathophysiology of itch in atomic dermatitis and psoriasis (SRG/14019). 2014-2017. Clinical PI: H.L. Tay, Non-Clinical PI: L.G. Ng
18. 12th JCO Grants: Development of cross-platform imaging probes for the study of neutrophil function in vivo (1431AFG108). 2013-2014. Project Director: L.G. Ng, Lead Investigators: B Liu and K Li.
19. A*STAR-MINDEF Grants: The development of a broadly protective influenza vaccine and visualization of immunological changes mediated by an immuno-modulating agent as mechanistic basis for effective medical countermeasures with military applications (10/1/50/19/669). 2011-2014.Lead Investigator: Gary Lau and Co-Investigator: L.G. Ng
20. Cancer Institute NSW Research Innovation Grants: Intravital cell-cycle imaging as a novel approach to design combined targeting strategies of independent signaling pathways in melanoma. 2009.CIA: N. Haass and CIB: L.G. Ng
21. NHMRC Project Grants: Real-time visualisation of dendritic cell responses during cutaneous Leishmania infection. 2009-2011. CIA: W. Weninger and CIB: L.G. Ng
22. The Clive And Vera Ramaciotti Foundations Establishment Grants: Visualising the structural changes of the lung during inflammatory responses by multiphoton microscopy. 2009. CIA: L.G. Ng
23. ARC FABL Network Support Grants: Development and optimisation of OPO-based multiphoton fluorescence imaging. 2008. CIA: A.L. Smith and CIB: L.G. Ng
24. The University of Sydney Bridging Support Grants: Real-time visualisation of dendritic cell responses in the skin. 2008.CIA: W. Weninger and CIB: L.G. Ng